What We Do

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What are our goals?

  • To support development of clinical trials targeting innovative, safer, biologically targeted and more effective treatments for children with rare forms of brain cancer.
  • To provide support for families with children battling brain tumours.
  • To collaborate with other individuals and organizations worldwide, working towards common goals.

Advancing Research: One Child Inspires Global Collaboration

  • 2008: Tali’s Fund supports ATRT research at SickKids Hospital in Toronto, Canada, mobilizing the largest global collaborative study of ATRTs involving over 40 countries.
  • 2015: Transformative publication shows that ATRT is not one disease.
  • 2016: Discovery of 3 subtypes of ATRTs, each responsive to different types of drugs.
  • 2018: Our research team hosts a conference for physicians & researchers from 88 centers around the world to discuss development of medicine personalized for individual patients to improve ATRT survival.
  • 2018: Dr. Huang’s research is recognized as highly significant and receives funding from the Stand Up to Cancer U.S. based grant program as part of a large international collaboration.
  • 2020: An international consensus document is developed for molecular classification of ATRTs to develop treatment matched to patient-specific ATRT subtypes.
  • 2020: Dr. Huang’s data on ATRT subtypes is used by the Children’s Oncology Group (the largest pediatric cancer trial consortium) to design a prospective global ATRT clinical trial.
  • 2021: Tumour and patient treatment data are being matched. Research is showing what works and what does not work for children with different types of ATRTs.

Next Steps

If all ATRT children are treated the same way, it is expected that approximately 40% of them will survive, and that radiation can be omitted safely without compromising survival.

Our researchers are now trying to determine whether more precise, less toxic treatment combinations can be matched to specific ATRT subtypes, allowing the remaining 60% of patients to also be successfully treated.

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2020 International consensus document is developed for molecular classification of ATRTs

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Publications

Letters of thanks

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